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    <title>Ryan Shea</title>
    <link>https://shea.io/</link>
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    <description>Essays by Ryan Shea — co-founder of Stacks, former FDA/HHS technology advisor, now building AI research tools for biotech and investing — on AI, biotech, markets, and human progress.</description>
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    <lastBuildDate>Fri, 28 Aug 2026 20:42:04 GMT</lastBuildDate>
    <item>
      <title>Biography</title>
      <link>https://shea.io/biography</link>
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      <pubDate>Fri, 28 Aug 2026 20:42:04 GMT</pubDate>
      <description>The life and career of Ryan Shea — from Princeton engineering to co-founding Stacks, advising HHS/FDA on AI, and building AI research tools for biotech and investing.</description>
      <content:encoded><![CDATA[<p>In the years leading up to college, I was the top scorer in the entire state for the New Jersey Math League, and I received perfect 800’s on the Math and Chemistry SAT 2’s.</p>
<p>In college, I studied Mechanical and Aerospace Engineering at Princeton University with minors in Computer Science and Robotics, where I was also President of the Princeton Entrepreneurship Club.</p>
<p>During and shortly after college, I worked two healthcare and biotechnology companies: ZocDoc and OmniActive Health Technologies. I also did a short stint shadowing a gastroenterologist.</p>
<p>In mid 2013, I became enamored by the world of bitcoin and cryptocurrency and this led me to co-found <a href="https://www.stacks.co/">Stacks</a>, the top platform for building smart contracts on Bitcoin and a top 100 cryptocurrency with a market cap of several hundred million dollars.</p>
<p>In 2019, I returned to the world of healthcare and biotech. For a few months at a time, I shadowed researchers and contributed programming expertise at the Endy Lab at Stanford, the Church Lab at Harvard, and the Esvelt Lab at MIT.</p>
<p>I spent the next few years doing a combination of investing in startups, launching my second company in the crypto space, and doing my own deep research into the fields of biotech and AI. Throughout these years I invested in over a dozen companies worth over a billion dollars.</p>
<p>In 2025, I worked as a Senior Advisor for Health and Human Services and the Food and Drug Administration. The initial project I worked on was <a href="https://www.fda.gov/news-events/press-announcements/fda-launches-agency-wide-ai-tool-optimize-performance-american-people">Elsa</a>, an AI chatbot like ChatGPT that is internal to FDA networks and is designed with features that are oriented around FDA workflows. Later in the year, I continued my work at FDA and built a system for <a href="https://www.fda.gov/news-events/press-announcements/fda-announces-major-steps-implement-real-time-clinical-trials">Real-Time Clinical Trials</a>, which was announced in April 2026.</p>
<p>This year, I launched two projects that were interesting to me in the world of AI: <a href="https://github.com/shea256/autofoundry">Autofoundry</a>, a CLI for spinning up GPUs across cloud providers and running AI experiments, and <a href="https://www.aiiq.org/">AI IQ</a>, an AI benchmarking site that scores frontier models on a human IQ scale.</p>
<p>Now, I’m working towards starting my next company at the intersection of AI and biotech or joining an awesome company in the space. I am always happy to connect with people who have similar interests to mine. If you’d like to help me hone in on my next endeavor, I’m looking to meet AI researchers interested in biotech as well as biotech researchers interested in AI.</p>]]></content:encoded>
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    <item>
      <title>Investments</title>
      <link>https://shea.io/investments</link>
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      <pubDate>Fri, 28 Aug 2026 20:42:04 GMT</pubDate>
      <description>Ryan Shea&apos;s featured startup investments, including unicorns like Supabase, Lattice, Mercury, Anchorage, OpenSea, and Filecoin.</description>
      <content:encoded><![CDATA[<h4>Featured Investments</h4>
<ul><li>Supabase, 2020, Unicorn</li><li>Lattice, 2016, Unicorn</li><li>Worldcoin, 2021, Unicorn</li><li>Mercury, 2019, Unicorn</li><li>Anchorage, 2018, Unicorn</li><li>OpenSea, 2018, Unicorn</li><li>Filecoin, 2017, Unicorn</li><li>Lightning, 2016, Growth Stage</li><li>CoinTracker, 2018, Growth Stage</li><li>Loyal, 2020, Growth Stage</li><li>Levels, 2016, Growth Stage</li><li>SiPhox, 2020, Growth Stage</li><li>Runwise, 2020, Growth Stage</li><li>Albedo, 2021, Growth Stage</li><li>Impossible Mining, 2022, Early Stage</li><li>Extropic, 2022, Early Stage</li><li>Privy, 2023, Exit to Stripe</li><li>Embark, 2016, IPO</li></ul>]]></content:encoded>
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    <item>
      <title>Favorite Books</title>
      <link>https://shea.io/books</link>
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      <pubDate>Fri, 28 Aug 2026 20:42:04 GMT</pubDate>
      <description>A collection of Ryan Shea&apos;s favorite books across fiction, philosophy, history, science, and technology.</description>
      <content:encoded><![CDATA[<h4>Philosophy &amp; Spirituality</h4>
<ul><li><strong>Finite and Infinite Games</strong> — James Carse</li><li><strong>Man's Search for Meaning</strong> — Viktor E. Frankl</li><li><strong>Tao Te Ching</strong> — Lao Tzu</li><li><strong>Meditations</strong> — Marcus Aurelius</li><li><strong>The Power of Now</strong> — Eckhart Tolle</li><li><strong>The Way to Love</strong> — Anthony de Mello</li><li><strong>Spiritual Enlightenment: The Damnedest Thing</strong> — Jed McKenna</li><li><strong>The Power of Myth</strong> — Joseph Campbell</li></ul>
<h4>Science Fiction</h4>
<ul><li><strong>Project Hail Mary</strong> — Andy Weir</li><li><strong>The Moon Is a Harsh Mistress</strong> — Robert Heinlein</li><li><strong>Leviathan Wakes (The Expanse, #1)</strong> — James Corey</li><li><strong>Dune</strong> — Frank Herbert</li><li><strong>Altered Carbon</strong> — Richard Morgan</li><li><strong>Neuromancer</strong> — William Gibson</li><li><strong>Snow Crash</strong> — Neal Stephenson</li><li><strong>Prey</strong> — Michael Crichton</li><li><strong>Foundation Trilogy:</strong> Foundation, Foundation and Empire, Second Foundation — Isaac Asimov</li><li><strong>Remembrance of Earth's Past Trilogy:</strong> The Three-Body Problem, The Dark Forest, Death's End — Liu Cixin</li></ul>
<h4>Science &amp; Systems</h4>
<ul><li><strong>QED: The Strange Theory of Light and Matter</strong> — Richard Feynman</li><li><strong>The Structure of Scientific Revolutions</strong> — Thomas S. Kuhn</li><li><strong>The Book of Why</strong> — Judea Pearl</li><li><strong>The Beginning of Infinity</strong> — David Deutsch</li><li><strong>Thinking in Systems</strong> — Donella Meadows</li></ul>
<h4>Business &amp; Entrepreneurship</h4>
<ul><li><strong>The Four Steps to the Epiphany</strong> — Steve Blank</li><li><strong>Founders at Work</strong> — Jessica Livingston</li><li><strong>The Hard Thing About Hard Things</strong> — Ben Horowitz</li><li><strong>Crossing the Chasm</strong> — Geoffrey A. Moore</li><li><strong>Zero to One</strong> — Peter Thiel</li><li><strong>The Design of Everyday Things</strong> — Donald A. Norman</li></ul>
<h4>Politics, Economics &amp; Society</h4>
<ul><li><strong>On Liberty</strong> — John Stuart Mill</li><li><strong>Antifragile</strong> — Nassim Taleb</li><li><strong>The Myth of the Rational Voter</strong> — Bryan Caplan</li></ul>
<h4>Biography &amp; History</h4>
<ul><li><strong>Sapiens</strong> — Yuval Noah Harari</li><li><strong>The Better Angels of Our Nature</strong> — Steven Pinker</li><li><strong>The Idea Factory</strong> — Jon Gertner</li><li><strong>Steve Jobs</strong> — Walter Isaacson</li><li><strong>Elon Musk</strong> — Ashlee Vance</li></ul>
<h4>Psychology &amp; Personal Development</h4>
<ul><li><strong>The Way of the Superior Man</strong> — David Deida</li><li><strong>King, Warrior, Magician, Lover</strong> — Robert Moore</li><li><strong>Iron John</strong> — Robert Bly</li></ul>
<h4>Literary Fiction</h4>
<ul><li><strong>Patriotism</strong> — Yukio Mishima</li><li><strong>The Alchemist</strong> — Paulo Coelho</li><li><strong>The Stranger</strong> — Albert Camus</li><li><strong>Siddhartha</strong> — Hermann Hesse</li><li><strong>The Kite Runner</strong> — Khaled Hosseini</li><li><strong>The Hobbit</strong> — J.R.R. Tolkien</li><li><strong>The Lord of the Rings Trilogy:</strong> The Fellowship of the Ring, The Two Towers, The Return of the King — J.R.R. Tolkien</li></ul>]]></content:encoded>
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      <title>Epistemology</title>
      <link>https://shea.io/epistemology</link>
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      <pubDate>Fri, 28 Aug 2026 20:42:04 GMT</pubDate>
      <description>Notes on knowledge and reason — fallibilism, critical rationalism, and why humanity&apos;s potential is unbounded.</description>
      <content:encoded><![CDATA[<p>Humanity's potential is unbounded. There are no limits to the human condition other than that which is forbidden by physics. This doesn't mean a better future is guaranteed, but it does mean that one is within our reach.</p>
<p>Rationality over dogmatism. Any and all principles should be presented to be critically inspected and justified via epistemology and reason, rather than be dogmatically accepted.</p>
<p>Every principle is meant to be questioned rather than blindly followed. Every principle found to be erroneous is meant to be changed rather than set in stone.</p>
<p>Follow the epistemological principle of fallibilism. Reject relativism, skepticism, and infallibilism. There is a truth and we can approach it. At the same time, however, this truth can never be reached or established with certainty. The process of understanding more about our world is an infinite journey.</p>
<p>Adopt the perspective of critical rationalism. Knowledge is not created through observation and logical conclusion. Rather, humans identify puzzles about the world around us, use our creativity to generate explanations, and test them through experience to see if they hold up in the physical world.</p>]]></content:encoded>
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      <title>Metaphysics</title>
      <link>https://shea.io/metaphysics</link>
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      <pubDate>Fri, 28 Aug 2026 20:42:04 GMT</pubDate>
      <description>Notes on objective reality, humanity&apos;s significance as universal explainers and constructors, and the origins of the universe.</description>
      <content:encoded><![CDATA[<h4>Reality</h4>
<p>There exists an objective reality. This is the foundation upon which the rest of my epistemology rests. Given that there is an objective reality, it then follows that this objective reality is capable of being perceived and measured, even though it can never be truly known with certainty.</p>
<h4>Humanity</h4>
<p>Humans are extraordinary. Humans are unique on Earth in that they are universal explainers and universal constructors. We have the potential for infinite knowledge and thus have infinite capacity for physical transformations. In this sense, humanity's place in the universe is significant, rather than insignificant.</p>
<h4>The Universe</h4>
<p>There is no good answer to the origins of the universe. Either (1) the universe just is or was created by something that just is (the dogmatic argument), or (2) the universe created itself (the circular argument), or (3) the universe was created by something that itself was created by something else ad infinitum (the regressive argument). I favor the circular argument. It is least unpalatable to surmise that the universe could have simply created itself. And perhaps the universe as self-creator and pervasive being across time and space that is one with all is what we refer to as God.</p>]]></content:encoded>
    </item>
    <item>
      <title>Ethics</title>
      <link>https://shea.io/ethics</link>
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      <pubDate>Fri, 28 Aug 2026 20:42:04 GMT</pubDate>
      <description>Notes on ethics — curing the world of evils by expanding consciousness and love. A work in progress.</description>
      <content:encoded><![CDATA[<p>(Work in progress)</p>
<p>All evils are due to insufficient consciousness or insufficient love.</p>
<p>We can cure the world of evils if we expand our love and expand our consciousness.</p>
<p>And that should be our highest calling.</p>]]></content:encoded>
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